Presentation Summary : SGLT2 Inhibitors in Phase 3 Development Empagliflozin Canagliflozin Dapagliflozin Ipragliflozin Empagliflozin: Change in A1C Randomized, double-blind, 12 week ...
Source : http://www.nysafp.org/images/uploads/misc/1326909268_SGLT-2%20powerpoint%20AFP.ppt
Presentation Summary : Role of the Kidney in T2DM - WorldWIDE Diabetes
Source : http://www.worldwidediabetes.org/wp-content/downloads/role-of-the-kidney.ppt
Presentation Summary : ... glucagon secretion Slow gastric emptying Increase satiety Exenatide Byetta Exenatide XR Bydureon Liraglutide Victoza SGLT2 inhibitors Increase urinary ...
Source : http://outpatient.aace.com/sites/all/files/T2DM_S5_Treatment_041813.ppt
Presentation Summary : Model-Based Meta-Analysis of HbA1c, Weight, and FPG in Type 2 Diabetes: Focus on SGLT2 inhibitors William S. Denney and Gianluca Nucci Pfizer Global R&D, Groton/New ...
Source : http://www.go-acop.org/sites/default/files/webform/posters/Denney-SGLT-2%20Poster-ACoP%202011.ppt
Presentation Summary : Several selective SGLT2 inhibitors (SGLT2i) are currently under development2,3. SGLT2 inhibition results in increased urinary glucose excretion (UGE) ...
Source : http://www.go-acop.org/sites/default/files/webform/posters/Nucci-SGLT2i-Poster-ACoP-2011.ppt
Presentation Summary : The Role of the Kidney in Glucose Control Hyperglycemia in Type 2 Diabetes Sodium Glucose Cotransporters Location of Sodium Glucose Cotransporters in the Kidney SGLT2 ...
Source : http://img.medscape.com/images/32761/779655_slides.ppt
Presentation Summary : ... compound should become active in early 2015 and we will be receiving milestone payments during the development of our SGLT2 Inhibitor.
Source : http://www.sironabiochem.com/wp-content/uploads/2014/02/SBM-Introduction-01292014.pptx
Presentation Summary : Rationale for SGLT2 Inhibitors. The SGLT2 is a glucose transporter responsible for 90% of glucose reabsorption. Selective SGLT2 inhibitors could reduce blood glucose ...
Source : http://www.inosteo.org/UserFiles/File/PowerPoint/2012%20IOA%20Annual%20Convention/Saturday/Advances%20in%20Type%202%20Diabetes.Novel%20Agents%20that%20Target%20the%20Kidney.Freeman.pptx
Presentation Summary : ... Mechanism of Action Dapagliflozin (DAPA) is a selective inhibitor of the renal sodium-glucose co-transporter 2 (SGLT2) ...
Source : http://aace.newshq.businesswire.com/sites/aace.newshq.businesswire.com/files/publication/file/Shoba_Ravichandran_AACE_2011_slides.ppt
Presentation Summary : New Approaches for the Management of Diabetes: Practical Considerations for Clinicians SGLT2 Inhibitors in Phase 3 Trials Dapagliflozin†: Reduction in FPG at Week ...
Source : http://img.medscape.com/images/32761/779657_slides.ppt
Presentation Summary : Specific SGLT2 inhibitors are being developed as a novel means of controlling hyperglycaemia in T2DM. Contribution of Tissues to Fasting Plasma Glucose. Liver. 80%.
Source : http://www.arkansasafp.org/wp-content/uploads/Niyaz-Gosmanov-M.D..pptx
Presentation Summary : Sodium-glucose-cotransporter-1 and -2 (SGLT1 & SGLT2) Reabsorb glucose. Renal gluconeogensis contributes 20-25% of total glucose production. Hepatic contribution.
Source : http://www.segageriatrics.com/wp/wp-content/uploads/2011/09/New-DMII-Treatments.pptx
Presentation Summary : SGLT2 inhibitor. Increase urinary excretion of glucose. Canagliflozin. Invokana. Sulfonylureas. Increase insulin secretion. Glimepiride. Amaryl or generic. Glipizide.
Source : http://outpatient.aace.com/sites/all/files/T2DM-S5-Treatment-051713.pptx
Presentation Summary : Diagram of Proximal Renal Tubular Cell Showing Secondary Active Transport of Glucose by SGLT2. Nair S. et al. J . Clin. Endocrinol. Metab. 2010;95:34-42.
Source : http://www.acponline.org/about_acp/chapters/mn/10mtg/cuddihy.ppt
Presentation Summary : ... Antiplatelet therapy Annual screening of complications Diabetic education New drugs in diabetes mellitus Selective SGLT2 Inhibitors Dapagliflozin ...
Source : http://www.tlaa.org/2012/timac_rename.php?timac_pdf_id=11
Presentation Summary : Review the role of the kidney in the maintenance of normal glucose homeostasis. 6. Discuss the role of the SGLT2 inhibitors in the treatment of Type 2 DM. 7. Define ...
Source : http://www.stdeu.org/files/Diabetes_flyer_2014_registration_form.ppt
Presentation Summary : DISCLOSURES. Served as a consultant to Sanofi-Aventis. PI on 2 clinical Trials (DPP4 – Takeda, SGLT2 – BI) Acknowledge Dr. David Lieb and The National Diabetes ...
Source : http://www.acponline.org/about_acp/chapters/va/13mtg/aloi_advancementdiabetes.pptx
Presentation Summary : New mechanism of action - SGLT2 inhibition. Dose related A1c reductions studied as monotherapy and in combination with SFU, DPP4, TZD, Basal Insulin.
Source : http://metrohealth.net/wp-content/uploads/2012/01/Wolfe-Winter-Update-2014-DM1.pptx
Presentation Summary : ... a relatively benign condition in humans Selective SGLT2 inhibitors have a novel & unique mechanism of action reducing blood glucose levels by increasing renal ...
Source : http://www.osteopathic.org/inside-aoa/events/omed/omed-presentations/Documents/2013%20OMED%20Presentations/cleveland-clinic-skugor-oral-antidiabetic-medications.ppt
Presentation Summary : Works as a SGLT2 inhibitor. Works at sodium-glucose cotransporter 2 in kidneys to prevent glucose being reabsorbed & thus to be lost to the urine.
Source : http://www.etsu.edu/com/cme/documents/grand_rounds/internalmedicine/Snyder.pptx
Presentation Summary : Glucose Transport. Early in the proximal tubule, there is a sodium-glucose cotransporter (SGLT2) that transports one sodium ion and one glucose molecule.
Source : http://criticalcaremedicine.pbworks.com/f/5+-+The+Physiology+of+the+Proximal+Tubule.pptx
Presentation Summary : SGLT2 inhibition reduces glucose reabsorption, resulting in the excretion of excess glucose in the urine. Reference: Han S. Diabetes 2008;57:1723–1729. Coronary.
Source : http://www.his-files.com/pdf/annual2013/presentations/0900_Braunwald.pptx
Presentation Summary : STUDY OBJECTIVE Adjunctive-to-insulin therapy with sodium-glucose cotransporter 2 (SGLT2) inhibition may improve glycemic control in type 1 diabetes ...
Source : http://care.diabetesjournals.org/content/suppl/2014/04/23/dc13-2338.DC1/DC13_2338.ppt
Presentation Summary : ... Mus musculus low affinity sodium-dependent glucose cotransporter (Sglt2) mRNA Length=2035 Score = 1465 bits (739), Expect = 0.0 Identities = 1452/1687 (86% ...
Source : http://www.snubi.org/~juhan/BGM/ppt/project/haeryun_CKD_project.ppt